Little Lilly is a lovely ladybug, who enjoys going to school with her bug friends and living with her parents, Mr. John and Ms. Mairy Ladybug.
Lilly is too young to fly, but when her mother is taken ill while her father is away, she must help her. The only way is to fly to Pittsbur, the bugs' city, and return with a special bugs' doctor who will be able to save Ms. Mairy.
With some help from a friendly bird, the Red-Headed, Lilly sets out on her quest to reach the doctor and they have a very adventurous journey, being caught by hunters and helped by some kind farm animals, before joining the sparrows' migration. In the meantime, Lilly's worried father and friends set out on a courageous rescue mission. Can Lilly and her mother both be saved?